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It was recently shown that pemetrexed may play a role in cisplatin resistance in lung cancer by increasing the expression of Orai3 calcium channels as well as the expression of certain ABC transporters like MDR1 and MRP-5 responsible for cisplatin efflux and therefore a reduction of the effect of cisplatin [16] As current therapies are based on the co-administration of pemetrexed and cisplatin, there may be interactions between pemetrexed and cisplatin, including a reduction in the therapeutic effects of cisplatin caused by pemetrexed

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If your ovaries are overstimulated you should not have sex, or use barrier contraception for at least four days

The Recommended Dietary Allowance (RDA) for vitamin B12 varies by age and condition: Adults: 2.4 mcg/day Pregnant women: 2.6 mcg/day Breastfeeding women: 2.8 mcg/day However, injection dosages are significantly higher and vary depending on the individuals condition

Blood tests can determine if you have a B12 deficiency and help your healthcare provider suggest the best treatment options