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Additionally, IS levels are influenced by dietary protein intake (particularly aromatic amino acids), gut transit time, and medications (phosphate binders, antibiotics)

Leal AD, Qin R, Atherton PJ, Haluska P, Behrens RJ, Tiber CH, Watanaboonyakhet P, Weiss M, Adams PT, Dockter TJ, Loprinzi CL (2014) North Central Cancer Treatment Group/Alliance trial N08CA-the use of glutathione for prevention of paclitaxel/carboplatin-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled study

The ligand is the molecule that binds reversibly to a specific molecule or group of molecules, enabling purification by affinity chromatography

This weight gain results in increased estrogen levels due to androgen conversion to estrogens by the enzyme aromatase and, in turn, produces an increase in glandular tissue of the breasts due to the imbalance of estrogen to testosterone (elevated estrogenandrogen ratio)