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Severe gastroparesis or significant gastric motility disorders constitute another important contraindication

Hepatitis damages the liver and can lead to cirrhosis

B.ZhangX.et al (2018)

Bai, Shiping, Leilei Wang, Yuheng Luo, Xumei Ding, Jun Yang, Jie Bai, Keying Zhang, and Jianping Wang

To address these gaps, we now emphasize the need for future RCTs to implement more rigorous participant stratification by baseline vitamin K status, sex, age, and disease risk profile, and to utilize higher-dose and longer-duration interventions with menaquinones, particularly MK-7, which demonstrate superior bioavailability and extrahepatic tissue targeting ( 54 )