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Of the 120 patients, 4 patients (3%) had preexisting IgG binding antibodies to FVIII, 13 patients (11%) had preexisting IgM binding antibodies to PEG, 11 patients (9%) had preexisting IgG binding antibodies to PEG FVIII, and 7 patients (6%) had preexisting IgM binding antibodies to PEGFVIII

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Organ-level expression of pleiotrophin (PTN), transgelin (TAGLN), WNT1 inducible signalling pathway protein 2 (WISP2), and chordin like 1 (CHRDL1) are shown

Amish type microcephaly is a severe autosomal recessive metabolic disorder characterized by severe microcephaly apparent at birth, profoundly delayed psychomotor development, brain malformations, and episodic encephalopathy associated with lactic acidosis and -ketoglutaric aciduria (89)