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In recent years, an increasing number of studies have focused on adjunctive therapeutic strategies aimed at further protecting dopaminergic neurons based on existing treatments, delaying disease progression, and improving patients quality of life

Abstract Aims/hypothesis There is a growing need for markers that could help indicate the decline in beta cell function and recognise the need and efficacy of intervention in type 1 diabetes

During sample collection an assessment as to whether an individual was affected with konzo was conducted following the WHOs 3 main criteria for diagnosis including evidence of (1) a visible symmetric spastic abnormality of gait while walking or running, (2) a history of onset of less than 1 week followed by a nonprogressive course in a formerly healthy person, and (3) bilaterally exaggerated knee or ankle jerks without signs of disease of the spine

Specifically, a robust computational tool, MSITracer, which leverages the metabolic profile provided by stable isotope tracing and laboratory-built, highly sensitive ambient airflow-assisted desorption electrospray ionization (AFADESI)-MSI 27 was introduced for spatial tracing metabolic network within tissues

A main limitation, which was only realized in recent years is that there is an OS independent pathway for generating F2-isoprostanes, catalysed by prostaglandin endoperoxide synthase [163]