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5.1 Nonpharmacologic approaches CR mitigates senescence-associated renal changes by activating SIRT1 and AMPK, blocking mTOR and NF-B signaling pathways, and inhibiting the activity of endothelin-1 (ET-1) (Wang et al., 2021), thereby promoting autophagy and reducing oxidative stress (Ning et al., 2013)

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This multidisciplinary research approach has three main advantages: firstly, it can efficiently identify potential novel therapeutic targets (Khan and Khan, 2025

The effect of N-acetylcysteine on biofilms: Implications for the treatment of respiratory tract infections

Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species