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Discordance between ex vivo potency and in vivo PK/PD has many potential causes, one of which, in the case of schistosomicidal agents, is the involvement of the host immune response

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Figure 7D ), a master transcription factor regulating antioxidant responses and ferroptosis, displays disease state-dependent expression changes reflecting transcriptional adaptive responses of renal cells to ferroptotic stress

Physiology (Bethesda) 35 , 391404 (2020)