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The most effective approach is to alternate their use

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[DOI] [PMC free article] [PubMed] [Google Scholar] 62.De Palma C., Morisi F., Pambianco S., Assi E., Touvier T., Russo S., Perrotta C., Romanello V., Carnio S., Cappello V., et al

People with megaloblastic anemia need to be tested for vitamin B 12 deficiency before treatment with folic acid, because if the person has vitamin B 12 deficiency, folic acid supplementation can remove the anemia, but can also worsen neurologic problems