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Third, PA calcification has been linked to hypoxia, in that hypoxia decreases the expression of serine protease granzyme B stored in the granules of T lymphocytes and natural killer cells, which inhibits store-operated calcium channels (SOCCs) as the main source of calcium mineral by attenuating non-canonical Wnt signals in SMCs, thus increasing calcification of the PA (141)

Polimanti R, Simonelli I, Zappasodi F, Ventriglia M, Pellicciari MC, Benussi L, Squitti R, Rossini PM (2016) Biological factors and age-dependence of primary motor cortex experimental plasticity

m1A regulated genes modulate PI3K/AKT/mTOR and ErbB pathways in gastrointestinal cancer

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