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Second, translational development should focus on dual-functional nanocarriers designed for striatal targeting and bloodbrain barrier penetrationusing DARPP-32-binding peptides to target affected MSNs and PEGylation to enhance brain entryloaded with mitochondria-directed ferroptosis modulators that both activate GPX4 and chelate iron, combined with mHTT-responsive release systems to avoid interference with normal neuronal function

Limitations of Available Evidence Research varies based on study design, dosing, and delivery method

Retailers are taking sides and the brands willing to bet on that convergence early are the ones positioning themselves at the front of what comes next

Most iron in the body is stored as hemoglobin

Golmohammadi et al