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Smith, E.E

The Infectious Diseases Society of America recommends amoxicillin-clavulanate rather than amoxicillin as first line treatment and doxycycline, levofloxacin, and moxifloxacin in patients allergic to penicillin.17 The emergence of bacteria resistant to current antibiotic therapies is a worldwide clinical threat

Additionally, they secrete antibacterial compounds, such as organic acids, hydrogen peroxide, and bacteriocins, that reduce pathogen viability (144)

They are rendered more hydrophilic by biochemical processes in the hepatocyte, yielding water-soluble products that are exported into plasma or bile by transport proteins located on the hepatocyte membrane and subsequently excreted by the kidney or gastrointestinal tract [19] ( Figure 1 )