glutathione radiation protection Frontiers Ionizing Radiation as a Source

GSH modulates monocyte recruitment and macrophage polarization

It plays a central role in redox homeostasis, detoxification of reactive oxygen species, and maintenance of cellular thiol balance across virtually every tissue type in the body

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Given that EtOH-induced mitochondrial dysfunction and ER stress are intimately involved in the pathogenesis of ALD, future studies to examine these pathways under the current experimental setting will provide important mechanistic information underlying the protection seen in GCLM KO mice

The International Society for Diseases of the Esophagus 2014, 2014