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The result is diabetic nephropathy that can progress to renal failure, peripheral and autonomic neuropathies causing pain, numbness, and orthostatic symptoms, retinopathy that threatens vision, and cardiovascular disease that remains the leading cause of death in diabetes

Second, the doses are small because the target is a high-affinity intracellular enzyme, not a receptor that needs saturating with milligrams of drug

From a theoretical pharmacological standpoint, combining a peptide with putative lipolytic activity (AOD 9604) with a potent triple incretin receptor agonist (retatrutide) could potentially amplify metabolic effects but this is speculative and raises the possibility of compounding adverse effects with no safety data to guide dosing or monitoring

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This is not a hypothetical scenario