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Rights and permissions About this article Cite this article Grabner, G.F., Xie, H., Schweiger, M

Int J Dermatol

Glutathione (GSH), a vital endogenous antioxidant, is the most abundant low-molecular-weight thiol in mammalian cells

In metabolic tissues, particularly adipose and skeletal muscle, ROS impair insulin signaling by altering adipokine profiles (decreased adiponectin and increased leptin/resistin) and by inhibiting key signaling molecules like IRS-1 and GLUT4, resulting in systemic insulin resistance

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