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By utilizing glutathione intravenous drips, fractionated lasers, and stem cell-derived exosomes, we correct epidermal hyperpigmentation, regulate melanin production at the source, and synthesize elastin for extreme dermal luminescence

134 Aged mice show a decrease in the reconstitution capability of their hematopoietic stem cells (HSCs), correlating with an increase in DNA damage 135,136 and with an increase in the levels of senescence effectors, such as p16INK4a

Front Cell Dev Biol 11:1332049 Zhang DD (2025) Thirty years of NRF2: advances and therapeutic challenges

53,54,55 These niche changes include increased expression of inflammatory cytokines such as CXCL14 and cell cycle inhibitors such as CDKN1C and CDKN2A, coupled with downregulation of ECM and adhesion genes, including CAV1 , SPRY1 , FN1 , and ITGB1