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Since then, amyloid and tau proteins have been sought in numerous biological media, including CSF, blood, urine, saliva, and skin, with varying degrees of success

J Biol Chem (2008) 283:2328894

A major advance came in 1913, when Santiago Ramn y Cajal, using the gold-sublimate method, described two key astrocyte subtypes: Protoplasmic astrocytes, found in grey matter and marked by fine, elaborate processes, and fibrous astrocytes, present in white matter and distinguished by longer, fiber-like extensions

Febuxostat can be used in patients with renal dysfunction as this is not a significant route of elimination