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GSTs exhibit a wide intracellular distribution, being localized in mitochondria (GSTA1), cytosol (alpha, mu, pi, and zeta) and membrane-bound (MGST1) isoforms (Aniya and Imaizumi, 2011

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Replenishing the nutritional status of the host by increasing vital amino acids such as cysteine to enhance GSH levels and selenium to improve selenium deficiency and facilitate selenoprotein (GSH peroxidases, thioredoxin reductases) expression can inhibit oxidative stress, modulating inflammation, suppressing endothelial dysfunction, and protecting vascular cells against apoptosis and calcification (He et al., 2017

Despite shelves full of topical products promising transformation, very few penetrate deep enough to activate proper regeneration