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Our patient was diagnosed with severe GSSD after neonatal onset, with symptoms including hemolytic anemia, hyperbilirubinemia and severe metabolic acidosis (intractable), urine-organic acid analysis results suggestive of the presence of 5-oxoprolinuria, and imaging results suggestive of central nervous system damage and developmental retardation in the infant at follow-up

Queen BL, Tollefsbol TO

A large preclinical toxicity program run across mice, rats, rabbits, and dogs found BPC-157 well tolerated with no serious treatment-related toxicity, no identifiable lethal dose, and no genotoxic or teratogenic signal, which is the strongest safety data point available by Xu 2020

However, the help of PRP on injury healing is controversial, for example, a clinical follow-up found no difference between PRP and controls, these controversies may be related to the different ways of preparing PRP, more studies are needed to confirm the exact efficacy of PRP in tendinopathy