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Osteoclast differentiation factor Denosumab (DMab) is a human monoclonal IgG2 antibody that inhibits bone resorption by binding and inhibiting the receptor activator of the NF-kB ligand (RANKL), an essential cytokine for osteoclastogenesis and bone resorption

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These findings not only deepen our understanding of CD pathophysiology but also position CEAAs, Cys, and Tyr as promising candidates for therapeutic targeting and biomarker development

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Conclusion Mild to moderate hyperhomocysteinemia seems to be an independent and causal risk factor for atherosclerotic vascular disease