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5c) by linking a ZBP1-specific DNA aptamer to an E3 ligand via an N-acyl-N-alkyl sulfonamide linker

Nyberg and colleagues

The literature search, article review, data extraction and results were completed by the PCRRT co-chairs, who submitted their results to the workgroup for discussion

While this construct mimicked the first TCR signal upon CAR binding to its target antigen, they lacked the second signal necessary for efficient T-cell activation