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Ajani has received honoraria from Lilly, Bayer, Novartis, Five Prime Therapeutics, Taiho Pharmaceutical, Genentech, and Roche, received research funding from Novartis, Bristol-Myers Squibb, Taiho Pharmaceutical, Roche/Genentech, MedImmune, Amgen, Lilly/ImClone, Merck, Delta-Fly Pharma, Gilead Sciences, and Takeda, and received travel accommodation expenses (not for this work) from Novartis, Bayer, and Five Prime Therapeutics

Unlike Rac1 and Cdc42 that can be palmitoylated on their C-terminus to facilitate their recruitment to the lipid raft on the plasma membrane where gamma-secretase was located, RhoA was found mainly in the non-raft fraction (Kumanogoh et al., 2001

doi: 10.1080/00207450902782083 206 KowalczykP.KaczyskaK.KleczkowskaP.Bukowska-OkoI.KramkowskiK.SulejczakD

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In the context of breast cancer mouse models, fibroblasts within lung metastases express cyclooxygenase 2 and produce PGE2