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In the selection of GPX homologs from blastp hits, very strict criteria (only the highest hit sequence) was applied to avoid the redundant sequences and alternative splices of the same gene

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However, other studies suggest that cyclosporin A upregulates gingival SHH (Sonic hedgehog protein) expression in vitro, while in vivo that inhibition of the SHH pathway counteracts the stimulatory effect of cyclosporin A on gingival fibroblast proliferation

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