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There have been several proteins that have been classified as NTFs based on the effects they have on neuronal survival, differentiation, maturation of electrophysical properties, and plasticity

Originally identified in human plasma in the early 1970s, this naturally occurring copper-binding tripeptide has since been detected in saliva and urine, suggesting a widespread and essential biological presence that acts as a cornerstone for systemic health

For instance, Galectin-13 promotes ferroptosis spread by reducing the membrane localization of SLC7A11 in neighboring cells, a process regulated by the PKCII-FOXK1 signaling axis with interindividual variability in activity (198)

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