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Most Common Side Effects Dry mouth Insomnia or disrupted sleep Increased heart rate or blood pressure Mild nausea (typically dose-related and temporary) Restlessness or mild anxiety in sensitive individuals Adverse events were mostly mild to moderate and occurred during early weeks of treatment

For example, after a 12-week cycle, a 4- to 6-week break is often sufficient for biomarkers to normalize

Funding This work was supported by the Natural Science Foundation Council of China (81922081and 81700780)

Vitamin B12 is a water-soluble vitamin, meaning the body does not store excess amounts in fat tissues

P., Lilley, K