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Key facts Prolia is most often a medical-benefit buy-and-bill drug administered in the clinic every 6 months billed under HCPCS J0897 per CMS Local Coverage Determination L33394 not a Part D pharmacy pickup

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Cell Mol Life Sci 77(6):11151133 Zhang ZZ, Lee EE, Sudderth J et al (2016a) Glutathione depletion, pentose phosphate pathway activation, and hemolysis in erythrocytes protecting cancer cells from vitamin C-induced oxidative stress

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Regulatory agencies require extensive clinical evidence before approval, and the absence of such data means safety and effectiveness remain uncertain