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Neuroreport 19(16):15891592

Harvey JW

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norepinephrine increases both total peripheral resistance, as well as systolic and diastolic blood pressure Note : Compensatory vagal reflexes tend to overcome the direct positive chronotropic effects on the heart (since both branches of the ANS innervate the SA node), but do not eliminate the positive inotropic effects on the ventricle (which does not have significant vagal innervation)

We further discuss emerging developments in the field, including the influence of the gut microbiota and gut-brain axis on TRP metabolism, alterations in KP activity in postpartum depression, and the potential for psychedelic compounds to modulate KP dynamics, highlighting the pathways promise as a source of biomarkers and therapeutic targets