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Other relevant interactions: Colchicine (used for gout) may affect B12 absorption with long-term use Chloramphenicol (rarely used antibiotic) may blunt the haematological response to B12 treatment Monitoring considerations: Patients taking loop or thiazide diuretics require careful monitoring when initiating B12 therapy in severe deficiency, due to the risk of hypokalaemia during rapid cell production

Flow cytometric analysis was performed on a Gallios Flow Cytometer (Beckman Coulter) or CytoFLEX (Beckmann Coulter) and evaluated using the Kaluza and cytExpert Flow Cytometry analysis software (Beckman Coulter)

[14] A dose of 200 mcg per day has been found to reduce TPO antibodies by about 50 percent within three months

ALS is a large glucoprotein that under physiological conditions are present in a two-fold molar excess (16)