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But so far, there havent been randomized, controlled trials in humans, the gold standard for determining whether a treatment actually works and is safe

For example, monosodium glutamate (MSG) and aspartame are food additives that can cause excessive stimulation of nerve fibers, possibly contributing to increased pain signaling

(11) This has led to the hypothesis that exogenous FOXO protein, such as FOXO4-DRI peptide, may help regulate optimal levels of FOXO proteins, thereby preventing or alleviating the progression of any NDDs associated with this mechanism