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The sirtuin family of NAD+-dependent deacetylases has received particular attention in longevity research

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Symptoms of Vitamin B12 deficiency anaemia include sore mouth and tongue, numbness and tingling in the arms and legs, memory loss and depression

Mechanistically, we found that NRF2 is required for the deposition of H3K27ac marks at sites of nascent transcription, including eRNAs

62 , 63 The correlation between the different biochemical variants, the site of genetic mutation, and the extent of hemolysis is a matter of current investigation