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Protocol Quick-Reference Anti-fibrotic therapy for kidney disease (preclinical) Dosing Amount Not standardized (preclinical IV/infusion doses) Frequency Single or chronic infusion (preclinical) Duration Acute to multiple weeks (study-dependent) Administration Route IV Timing KP1 administered as IV bolus in mouse fibrosis models

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Upon adding CuSO 4 , the recombinant GHK peptide was converted to a GHK-copper complex, with the characteristic ligand-to-metal charge transfer bands at 246 nm

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