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Hence, excess iron from diet (50 mg/kg ferrous sulfate) and/or supplementation alters the intestinal phenotype and, by extension, modulates the regulation of ferroptosis [60]

Lysosomal acidification mechanisms

In the susceptible subject with KDDD, AFs cause direct DNA and tissue injury and initiate a cascade of massive inflammatory response

2.2.3 8-hydroxy-2-deoxyguano-sine (8-OHdG) Reactive oxygen radicals attack the carbon atom at the 8-position of the guanine base in the DNA molecule, producing the oxidation product 8-OHdG

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