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Telomerase is the enzyme that extends and repairs telomeres, the protective DNA sequences at the ends of chromosomes that shorten with each cell division

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Since -tubulin holds an essential role in microtubule nucleation, the novel finding that it is also susceptible to 4-HNE modification offers a plausible explanation for the spindle deformities, microtubule disorganisation and ensuing aneuploidy observed in this, and other studies of aged oocytes 3,4,5, 86, 87

Qiu Z, Zhang H, Xia M, et al

Ishizawa J, Jacamo RO, Kojima K, Chachad D, Ruvolo V, Ruvolo P, Zhang W, Tabe Y, Konopleva M, Devine W, Lindquist S, Porco, Jr JA, Whitesell L, and Andreeff M