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doi:10.14219/jada.archive.2012.0020 Cotler HB, Chow RT, Hamblin MR, Carroll J

Both: Dose, route, and duration matter

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society , 60 Suppl 7 , 115122

These gastrointestinal side effects typically peak during weeks 6-8 and resolve significantly by week 12

As to the fatigue, I (a patient, not a practitioner, although I do have a HEAVY background in science), I got tremendous help from Sam-E for liver and neurotransmitter-production support