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TCM decoction like Gegen Qinlian Tang (GQD) have demonstrated their ability to improve high blood sugar and protect pancreatic function by modulating the structure of gut microbiota, thereby restoring intestinal permeability and suppressing inflammation in T2DM rats (Tian et al., 2021)

[5] [7] At dosages exceeding 5 grams, there is a potential risk for more severe adverse effects, including renal dysfunction, blood toxicity, and neurological symptoms

This indicates that the upregulation of glutathione synthesis within TLS is possibly reflected by increased urinary GSH concentrations

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