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administration ATO group ( n = 5, respectively)

This in turn may lead to increased vascular tone (narrowing of vessels) and enhanced platelet aggregation, both of which may contribute to red cell stasis, sickling, and (in some instances) thrombosis

At this point, in each well the buffer was replaced with 600 L uptake buffer containing compound and 0.12 Ci (80-110 mCi/mmol) of L-[3,3- 14 C]-cystine (Perkin Elmer) and incubated for 3 minutes at 37 C

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However, in the context of mitochondrial dysfunction, the balance between ROS production and antioxidant defense mechanisms is disrupted, leading to an excessive accumulation of ROS [10]