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In silico modeling and experimental validation confirm a prominent role of C8 for dimer formation and aggregation

Clinical studies have demonstrated significant reductions in trunk fat and visceral fat specifically, with less impact on subcutaneous fat and lean mass targeting the most metabolically dangerous fat depot

doi:10.1016/j.gde.2005.09.013

Constitutional Megaloblastic Anemia Constitutional megaloblastic anemia (CMegA) encompasses a heterogeneous group of autosomal recessive conditions affecting cobalamin (vitamin B12) metabolism (113)