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A recent study characterised the metabolic profile of these eosinophil subsets and found that inflammatory eosinophils relied more on glycolytic respiration, whereas resident eosinophils were more dependent on OXPHOS and had higher number of mitochondria ( A study by Jones et al demonstrated that IL-5 and GM-CSF induce glycolysis, OXPHOS and TCA cycle activity in blood eosinophils from both atopic and non-atopic subjects

Cancer 5 , 10101023 (2024)

Only one patient discontinued treatment due to this side effect ( The rate of serious adverse events actually trended lower with brensocatib treatment compared to placebo

10.2147/IJN.S203352 86 GhebretatiosM.SchalyS.PrakashS