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In order to examine how was the behavior when considering our complete population sample, we analyzed the data exhibited in the following figures and table

Hypertension, another symptom of metabolic syndrome, showed variations in DNA modulations since it has been reported in hypertensive rat models a hypomethylation of the (pro)renin gene [142] or of the adrenergic 1 gene [143]

Model analysis Selection of parameters for estimation The methodology to select parameters for estimation involves first conducting local sensitivity analysis (LSA) to obtain a set of important parameters, and then determining from this set of parameters which are identifiable, that is for which parameters a value can be identified from the data, taking into account the model structure

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