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These observations led to the conclusion that BCAP is an upstream adapter that connects TLR signals with the optimal aerobic glycolysis in macrophages, resulting in the lactate production necessary for proper histone Kla to promote the rescue of gene expression

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Immunity 2007

Among the drug-induced DNA lesions, abasic (apurinic/apyrimidinic, AP) sites are one of the most common types in cells, and can lead to more deleterious lesions such as DNA strand breaks [4, 5]

Can be administered subcutaneously (systemic effect) or intramuscularly at specific injury sites