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2 Advertised as safe in doses up to 4000 mg every 24 hours by the United States Food and Drug Administration (FDA), consumption at this dose generally does not yield any toxic effects

PRLM treatment also decreases the secretion of inflammatory cytokines, including TNF-, IL-1, and IL-6, and prevents tissue injury by inhibiting inducible nitric oxide synthase, COX-2, and myeloperoxidase activation [270,271,272]

All PK and in vivo experiments were conducted in accordance with the animal welfare procedures and were approved by the UTMDACC IACUC