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Native nCRP binds FcRI/CD89 on neutrophils and macrophages, and, in neutrophils, nCRP induces FcRI surface expression, phagocytosis and TNF- secretion (179)

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On the other hand, all exogenous antioxidants support prooxidation chemistry that can also trigger OS by promoting the release of ROS under certain conditions, which is essential to kill neoplastic cells by inducing different cell death pathways to exert chemotherapeutic effects [60, 146, 197,198,199,200, 208, 213, 259]

formation of blood cells outside of their normal site in the bone marrow), variable reductions in the levels of circulating blood cells, increases in the circulating levels of the precursors to the latter cells, abnormalities in platelet precursor cell maturation, and the clustering of grossly malformed megakaryocytes in the bone marrow

doi: 10.1016/j.cyto.2015.10.001 11 DavoineFLacyP