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The most explored mechanisms are inflammation, the induction of apoptosis, destruction of the blood-testis barrier, and oxidative stress (34, 35)

falciparum 3D7 strain was generally more susceptible to these changes than the resistant Dd2 strain

These observations raise the possibility that UBQLN2 is a common catalyst for multiple aggregation-prone proteins, providing a mechanistic link to the frequent co-occurrence of -syn and tau pathologies in PD (Cisbani et al, 2017

Niki E, Noguchi N, Tsuchihashi H, Gotoh N

Some clinical studies have documented reductions in high-sensitivity C-reactive protein (hsCRP) among patients treated with tirzepatide for type 2 diabetes or obesity