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S.PintoV.GrahamM.AbgueguenE.BarnesM.et al (2018)

1 Background Autoimmune thyroiditis (AITD) is a T-cell-mediated, organ-specific autoimmune disease that mainly manifests as Hashimotos thyroiditis (HT) and Graves disease (GD) (Lee et al., 2015)

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RNR function can be directly inhibited by the small molecules gemcitabine (Gem) and hydroxyurea (HU), which serve as analogs of cytidine to inhibit dNTP synthesis (Krakoff et al, 1968