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15, 20, 30, 50, maybe one hundred POUNDS of fat

The first is the isoelectric point, abbreviated pI, which is the pH at which a peptide carries no net electrical charge

Rood explains

The elderly (reduced absorption) Pernicious anemia Vegetarians / Vegans (low dietary B12) People taking metformin or acid reflux medications (PPIs) Post-bariatric or gastric-bypass patients Genetic variants in MTRR , MTR , or TCN2 What Has B12 Been Studied For