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This suggests that modulating E1 activators could influence ion channel function and electrical activity in the heart, potentially offering a therapeutic avenue for arrhythmias

Jain N, Lamb A, O'Brien S, Konopleva M, Jabbour E, Ravandi F, Zhuang Z, Jorgensen J, Lin P, Pierce S, Thomas D, Rytting M, Borthakur G , Kadia T, Cortes J, Kantarjian H, Khoury J

Methods: Between March 2022 and April 2024, candidates for LT who were pre-frail by the liver frailty index (LFI) were recruited

A phase III trial involving 606 elderly AML patients demonstrated reduced risk of health-related quality of life (HRQoL) deterioration at 2 months with SGI-110 versus intensive chemotherapy (76% vs

This creates a bottleneck: inflammatory signaling after tendon microdamage can't recruit sufficient repair cells, and nutrient delivery to the injury site is limited