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Figure 2 3.3 GAMs reveal the association between maternal UA levels across early- to mid-gestation and HDP outcomes In our GAMs models using log-transformed maternal uric acid [log(UA)] ( Supplementary Figure S1 ) as a continuous predictor, the associations between UA levels and the risk of HDP diseases varied across gestational weeks, with distinct temporal patterns to different subtypes of HDP

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Studies indicate that upon Cu 2+ binding, the hydrophobic non-amyloid- component (NAC) domain becomes more solvent-accessible, facilitating initial hydrophobic interactions that form toxic oligomers (178, 179)

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