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In several serious diseases, especially those related to aging, oxidative stress is often the original triggering factor

After aptamer (AS1411) was installed onto the outermost protective layer of 3D DNA shell, the resulting nanovehicles can easily enter target HeLa cells by active binding to specific surface receptors (Targeted Delivery, Controlled Release and Gene Silencing Activity, Supplementary Figs

However, cysteine depletion, GPX4 inactivation, and iron overload cause cells to experience metabolic stress or ferroptotic cell death

10.3389/fmicb.2011.00005 13 ChoY

Extensive research efforts have been made to identify approaches to effectively deliver medication to the brain