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The impact of biotechnology products on pharmaceutical industries and new therapeutics can be illustrated by the fact that a remarkable percentage of recent drug approvals by the FDA are in the biological category (recombinant proteins and peptides, monoclonal antibodies, etc.)

Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function

There is some evidence that long-term corticosteroid use can increase the risk of cataracts and glaucoma, although this is more common with oral or injected steroids

Strong neurogenesis, angiogenesis, synaptogenesis, and antifibrosis of hepatocyte growth factor in rats brain after transient middle cerebral artery occlusion

The main reason is receptor desensitization : continuous stimulation of the same receptor makes cells less responsive over time, so a planned off period lets the receptor resensitize