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Hadi et al., 2025)

Trends Pharmacol Sci 16: 368374

Each factor serves distinct roles: PPAR gamma coactivator 1 alpha (PGC-1) initiates metabolic programs, PRDM16 (PR domain containing 16) modifies chromatin structure to enable differentiation, and FGF21 (fibroblast growth factor 21) enables heat production in mature cells ( 3.4 Pink AT: dynamic plasticity in mammary gland development and lactation Pink AT (PAT) showcases remarkable plasticity, forming from subcutaneous WAT during pregnancy and lactation