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Sustained hyperglycemia induces early retinal neurodegeneration, manifested as the loss of retinal ganglion cells, photoreceptors, and other neuronal populations (42), through mechanisms including oxidative stress, chronic low-grade inflammation, glutamate-mediated excitotoxicity, and mitochondrial dysfunction, all of which converge to promote neuronal apoptosis (89, 90)

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Because many of these risk factors are potentially modifiable or manageable, a substantial proportion of cancer cases could be possibly avoided through tailored prevention strategies